Placental DNA methylation at term reflects maternal serum levels of INHA and FN1, but not PAPPA, early in pregnancy

Serum levels of IL-17A increase in Asthma but not in accordance with Serum level of IgE and Asthma Severity

Background and Aims: Recent evidence suggests that T helper (Th) 17 cells are involved in the emergence of asthma. Th17 cells have a key role in inducing inflammation in asthmatic airways thus Interleukin (IL)-17A, the main cytokine of Th17, contributes to airways inflammation. Materials and Methods: We evaluated the level of IL-17A and total immunoglobulin E (IgE) in sera of 100 asthmatic p...

short-term pre-pregnancy health education may improve maternal nutrition behavior, but not nutrition self-efficacy

Maternal serum levels of interleukin-6 and β-hCG in women with hyperemesis gravidarum in the first trimester of pregnancy

Background and Objective: Hyperemesis gravidarum (HG) is defined as vomiting sufficiently severe to produce weight loss, dehydration, electrolyte abnormalities. Interleukin-6 (IL-6), a pro-inflammatory and trophoblast-derived cytokine has ability to induce trophoblasts to secrete human chorionic gonadotropin (hCG). The purpose of our study was to assay the level of IL-6 and β-hCG in serum of pr...

Serum human placental lactogen (HPL) levels in normal pregnancy.

It is now well established that human placenta secretes a protein hormone Human Placental Lactogen (HPL), also referred to as placental Somatomarnmotropin. It shows immunological crossreactivity with pituitary growth hormone and possesses both mammotropi.c and somatotropic effects (Jasiomovich and Maclaren, 1962, Kaplan and Grumbach 1968). This hormone is produced by syncytiotrophoblast layer o...

Maternal DNA Methylation Regulates Early Trophoblast Development

Critical roles for DNA methylation in embryonic development are well established, but less is known about its roles during trophoblast development, the extraembryonic lineage that gives rise to the placenta. We dissected the role of DNA methylation in trophoblast development by performing mRNA and DNA methylation profiling of Dnmt3a/3b mutants. We find that oocyte-derived methylation plays a ma...